The medical letter on drugs and therapeutics.

Inhibitors and inducers of CYP enzymes and P-glycoprotein.

Fidaxomicin (Dificid) for Clostridium difficile infection.

Volume 87, Number 3 www.aafp.org/afp American Family Physician 211 Fidaxomicin (Dificid) is an oral macrolide antibiotic labeled for the treatment of Clostridium difficile–associated diarrhea in adults. It primarily exhibits activity against species of clostridia, mainly C. difficile, while having no or limited activity against normal gastrointestinal flora. It joins the standard treatments of ...

Methylnaltrexone (Relistor) for opioid induced constipation.

www.aafp.org/afp Volume 82, Number 6 ◆ September 15, 2010 Methylnaltrexone (Relistor) is labeled for the treatment of opioid-induced constipation in patients with advanced illness who have not responded to laxative therapies.1 As a selective antagonist of peripheral mu-opioid receptors, methylnaltrexone inhibits opioidinduced gastrointestinal (GI) hypomotility without central nervous system eff...

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Alfuzosin (uroxatral)--another alpha1-blocker for benign prostatic hyperplasia.

EDITOR: Mark Abramowicz, M.D. DEPUTY EDITOR: Gianna Zuccotti, M.D., M.P.H., Weill Medical College of Cornell University CONSULTING EDITOR: Martin A. Rizack, M.D., Ph.D., Rockefeller University CONTRIBUTING EDITOR: Philip D. Hansten, Pharm.D., University of Washington ADVISORY BOARD: Jules Hirsch, M.D., Rockefeller University; James D. Kenney, M.D., Yale University School of Medicine; Gerald L. ...